韩通个人简介

韩通，男，1991.1，博士，讲师。

◆ 研究方向：

研究方向一：天然来源先导化合物的成药性改造、活性评价和作用机制研究

研究方向二：天然活性分子的获得及结构的确证

◆ 教学工作：

本科生课程：《药物代谢动力学》

◆ 教育经历：

2009.09−2013.06 佳木斯大学药学院药学专业理学 学士

2013.09−2018.06 沈阳药科大学中药学院天然药物化学专业 理学博士（硕博连读）

◆ 工作经历：

2018.09−至今威斯尼斯人老品牌官网 讲师

◆ 科研教研项目：

1.  灯盏乙素苷元磷酸酯型前药的设计及合成，威斯尼斯人老品牌官网三横三纵支持计划，2019.08−2022.08（主持人）

2.  灯盏乙素苷元衍生物的合成及抗肿瘤作用机制研究，威斯尼斯人老品牌官网学成、引进人才科研启动计划项目，2018.09−2028.09（主持人）

3.  基于甜菊苷和冬凌草甲素复杂母核结构高内涵化合物库的构建和抗肿瘤活性评价，国家自然科学基金面上项目，2018.01−2021.12（第4位）

4.  ent-贝壳杉烷二萜二聚体衍生物的合成，抗肿瘤活性评价和机制研究，国家自然科学基金青年科学基金项目，2016.01−2018.12（第6位）

5.  骆驼蓬属植物中靶向G-四链体的新颖生物碱类成分的发现及其抗肿瘤活性研究，国家自然科学基金面上项目，2018.01−2021.12（第10位）

◆ 代表论文：

1.  Tong Han,Baojia Sun, Mingying Wang, Xu Li, Keguang Cheng, Zhanlin Li, Jiao Bai, Huiming Hua, Dahong Li. Hybrids of scutellarein and benzoic acid mustard with improved antiproliferative activity and selectivity [J]. Eur. J. Med. Chem., 2018, 158: 493501.

2.Tong Han,Kangtao Tian,Huaqi Pan,Yongxiang Liu,Fanxing Xu,Zhanlin Li, Takahiro Uchita, Ming Gao,Huiming Hua,Dahong Li^*. Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation[J]. Eur. J. Med. Chem.,2018, 150: 5363.

3. Tong Han,Jia Li,Jingjing,Xue, HeLi, Fanxing Xu^*,Keguang Cheng,Dahong Li^*,Zhanlin Li, Ming Gao,Huiming Hua^*. Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation[J]. Eur. J.Med.Chem.,2017, 135, 270281.

1.  Dahong Li, Tong Han, Liping Guan, Jiao Bai, Nan Zhao, Zhanlin Li,Xin Wu*,Huiming Hua*. New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity[J]. Nat. Prod. Res., 2016, 30: 1116. (co-first author)

2.  Cuicui Jia,Tong Han, Jun Xu,Shengge Li, Yating Sun,DaHong Li,ZhanLin Li*,Huiming Hua*. A new biflavonoid and a new triterpene from the leaves of Garcinia paucinervisand their biological activities[J]. J. Nat. Med., 2017, 71: 642649.

3.  Dahong Li, Tong Han, Jie Liao, Xu Hu, Shengtao Xu, Kangtao Tian, Xiaoke Gu, Keguang Cheng*, Zhanlin Li, Huiming Hua*,Jinyi Xu*. Oridonin, a promising ent-kaurane diterpenoid lead compound.Int. J. Mol. Sci., 2016, 17: 575.

4.  Dahong Li, Tong Han, Kangtao Tian, Shuang Tang, Shengtao Xu, Xu Hu, Lei Wang, Zhanlin Li, Huiming Hua^*, Jinyi Xu^*. Novel nitric oxide-releasing spirolactone-type diterpenoid derivatives with in vitro synergistic anticancer activity as apoptosis inducer. Bioorg. Med. Chem. Lett., 2016, 26: 4191−4196.

5.  Dahong Li, Tong Han, Shengtao Xu, Tingting Zhou, Kangtao Tian, Xu Hu, Keguang Cheng*, Zhanlin Li, Huiming Hua*, Jinyi Xu*. Antitumor and antibacterial derivatives of oridonin: A main composition of dong-ling-cao. Molecules, 2016, 21: 575.

6.  Dahong Li, Tong Han, Xu Hu, Kangtao Tian, Shengtao Xu, Tingting Zhou, Keguang Cheng^*, Zhanlin Li, Huiming Hua^*, Jinyi Xu^*. Synthesis, cytotoxicity and antimicrobial activity of new enmein-type kauranoid diterpenoid derivatives. Anti-cancer Agents in Med. Chem., 2017, 17: 1679−1688.

7.  Dahong Li, Xu Hu, Tong Han, Shengtao Xu, Tingting Zhou, Zhenzhong Wang*, Keguang Cheng, Zhanlin Li, Huiming Hua*, Wei Xiao,Jinyi Xu*. Synthesis, biological activity, and apoptotic properties of NO-donor/enmein-type ent-kauranoid hybrids. Int. J. Mol. Sci., 2016, 17: 747.

8.  Wenjia Kang, Dahong Li,Tong Han, Lin Sun, Yanbin Fu, Chunmei Sai, Zhanlin Li*, Huiming Hua*. New chalcone and pterocarpoid derivatives from the roots of Flemingiaphilippinensis with antiproliferative activity and apoptosis-inducing property [J]. Fitoterapia, 2016, 112: 222−228.

9.  Dahong Li, Xu Hu, Tong Han, Jie Liao, Wei Xiao*, Shengtao Xu, Zhanlin Li, Zhenzhong Wang, Huiming Hua*, Jinyi Xu*. NO-releasing enmein-type diterpenoid derivatives with selective antiproliferative activity and effects on apoptosis-related proteins. Molecules, 2016, 21: 1193.

10.Nan Zhao, Kang-tao Tian, Ke-guang Cheng, Tong Han, Xu Hu, Da-hong Li*, Zhan-lin Li, Huiming Hua*. Antiproliferative activity and apoptosis inducing effects of nitric oxide donating derivatives of evodiamine. Bioorg. Med. Chem., 2016, 24: 2971−2978.

11.Chunmei Sai, Dahong Li, Shengge Li, Tong Han, Yongzhi Guo, Yuehu Pei, Jiao Bai,Yongkui Jing, Zhanlin Li*, Huiming Hua*. Racemic alkaloids from Macleaya cordata: structural elucidation, chiral resolution, and cytotoxic, antibacterial activities [J]. Rsc Adv., 2016, 47: 41173−41180.

12.Kangtao Tian, Fanxing Xu, Xiang Gao, Tong Han, Jia Li, Huaqi Pan*, Linghe Zang, Dahong Li*, Zhanlin Li, Takahiro Uchita, Ming Gao, Huiming Hua*. Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents [J]. Eur. J. Med. Chem., 2017, 136: 131−143.

13.Xu Hu, Yan Wang, JingjingXue, Tong Han, Runwei Jiao, Zhanlin Li*, Weiwei Liu, Fanxing Xu, Huiming Hua*, Dahong Li*. Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity [J]. Bioorg. Med. Chem.Lett., 2017, 27: 4989−4993.

14.Dahong Li, Jianyong Li, ChunmeiXue, Tong Han, Chunmei Sai, Kaibo Wang, Jincai Lu, Yongkui Jing, Huiming Hua, Zhanlin Li*. Antiproliferative dimeric aporphinoid alkaloids from the roots of Thalictrum cultratum [J]. J. Nat. Prod., 2017, 80: 2893−2904.

15.Chunmei Sai*, Dahong Li, Shengge Li, Tong Han, Yongzhi Guo, Zhanlin Li*, Huiming Hua*. LC-MS guided isolation of three pairs of enantiomeric alkaloids from Macleaya cordata and their enantioseparations, antiproliferative activity, apoptosis-inducing property [J]. Sci. Rep., 2017, 7: 15410.

◆ 授权专利：

1.  一类含有苯甲酸氮芥片段的化合物及其制备方法和用途，CN 109134487 B，2019，第3位

2.  一类硝酸酯NO供体型灯盏乙素衍生物及其制备方法和用途，CN 106928292 B，2019，第3位

3.  一类具有抗肿瘤活性的呋咱类NO供体型灯盏乙素衍生物及其制备方法和用途，CN 106883277 B，2019，第3位

4.  一类具有抗肿瘤活性的呋咱NO供体型灯盏乙素衍生物及其制备方法和用途，CN 106928293 B，2019，第4位

5.  布雷菲德菌素A的4-位呋咱NO供体型衍生物的制备方法及用途，CN 106928201 B，2019，第6位

6.  一类具有抗肿瘤活性的硝酸酯类NO供体型吴茱萸碱衍生物，CN201610020347.1，2017，第6位

7.  一类具有抗肿瘤活性的呋咱类NO供体型吴茱萸碱衍生物，CN201610016630.7，2017，第6位